Rabbit anti‑Human ACKR3 / CXCR7 Polyclonal RW-A1439-50

Antibody: ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody, Application: IHC, IHC-P, WB, Reactivity: Human, Horse, Format: Unconjugated, Unmodified, Descriptio: Atypical chemokine receptor 3 (ACKR3) controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. ACKR2 acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. It is required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival.

References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804, Targe: Human ACKR3 / CXCR7, Synonym: ACKR3 | Chemokine orphan receptor 1 | CMKOR1 | CXCR7 | CXC-R7 | GPRN1 | RDC1 | RDC-1 | CXCR-7 | G-protein coupled receptor 159 | GPR159, Hos: Rabbit, Reactivit: Human, Horse (tested or 100% immunogen sequence identity), Predicte: Monkey, Dog (at least 90% immunogen sequence identity), Clonalit: Polyclonal, Conjugation: Unconjugated, Purificatio: Immunoaffinity purified, Modification: Unmodified, Immunoge: Synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human CXCR7. Percent identity with other species by BLAST analysis: Human, Horse (100%); Gorilla, Gibbon, Monkey, Marmoset, Dog, Elephant (94%); Mouse, Rat, Hamster (88%); Bat, Bovine, Rabbit, Pig, Opossum (82%)., Epitop: Cytoplasmic Domain, Specificit: Human CXCR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins., Application: IHC
IHC - Paraffin (4 µg/ml)
Western blot, Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more: None, Presentatio: PBS, 0.1% Sodium Azide, Storag: Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About ACKR3 / CXCR: Uniprot: P25106 NCBI: NM_020311 NP_064707.1

Cat: RW-52-4357-138