Rabbit anti‑Human ACKR4 / CCRL1 / CCR11 Polyclonal RW-A1441-50

Antibody: ACKR4 / CCRL1 / CCR11 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody, Application: IHC, IHC-P, Reactivity: Human, Mouse, Rat, Bat, Dog, Horse, Pig, Rabbit, Format: Unconjugated, Unmodified, Descriptio: Atypical chemokine receptor 4 (ACKR4) controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. ACKR4 plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. ACKR4 negatively regulates CXCR3-induced chemotaxis and regulates T-cell development in the thymus.

References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804, Targe: Human ACKR4 / CCRL1 / CCR11, Synonym: ACKR4 | C-C CKR-11 | CC-CKR-11 | CC chemokine receptor-like 1 | CCR11 | CCX CKR | C-C chemokine receptor type 11 | CKR-11 | CCRL1 | VSHK1 | CCR-11 | CCX-CKR | PPR1, Hos: Rabbit, Reactivit: Human, Mouse, Rat, Bat, Dog, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity), Predicte: Monkey, Bovine, Hamster (at least 90% immunogen sequence identity), Clonalit: Polyclonal, Conjugation: Unconjugated, Purificatio: Immunoaffinity purified, Modification: Unmodified, Immunoge: Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human CCRL1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig (100%); Marmoset, Bovine, Hamster, Opossum (94%); Turkey, Chicken, Xenopus (81%)., Epitop: Cytoplasmic Domain, Specificit: Human CCRL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CCR6 (63%)., Application: IHC
IHC - Paraffin (24 µg/ml), Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more: None, Presentatio: PBS, 0.1% Sodium Azide, Storag: Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About ACKR4 / CCRL1 / CCR1: Uniprot: Q9NPB9 NCBI: NM_016557 NP_057641.1

Cat: RW-52-4396-150