Rabbit anti‑Human ACP5 / TRAP IgG Recombinant Monoclonal RW-C751319-20

Antibody: ACP5 / TRAP Rabbit anti-Human Recombinant Monoclonal (ACP5/2336R) Antibody, Application: IHC-P, Reactivity: Human, Format: Unconjugated, Unmodified, Other formats: Azide-free, Carrier-free, Descriptio: TRAP antibody RW-C751319 is an unconjugated rabbit recombinant monoclonal antibody to human TRAP (ACP5). Validated for IHC., Targe: Human ACP5 / TRAP, Synonym: ACP5 | SPENCDI | TrATPase | Type 5 acid phosphatase | Tartrate-resistant acid ATPase | TR-AP | TRACP5b, Hos: Rabbit, Reactivit: Human (tested or 100% immunogen sequence identity), Clonalit: IgG Recombinant Monoclonal, Clon: ACP5/2336R, Conjugation: Unconjugated, Purificatio: Protein A/G purified, Modification: Unmodified. Also available Azide-free, Carrier-free., Immunoge: Recombinant full-length human ACP5 protein. Antigen Molecular Weight: 35 kDa, Specificit: It recognizes a protein of 35 kDa , which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts., Application: IHC - Paraffin (1 - 2 µg/ml), Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more: None, Usag: Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined., Presentatio: 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide, Storag: Store at 2°C to 8°C for up to 2 years., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About ACP5 / TRA: Uniprot: P13686 NCBI: NM_001611 NP_001602.1

Cat: RW-52-5041-132