Rabbit anti‑Human CCDC6 Polyclonal RW-A11151-50

Antibody: CCDC6 Rabbit anti-Human Polyclonal Antibody, Application: IHC-P, Format: Unconjugated, Unmodified, Descriptio: CCDC6 encodes a coiled-coil domain-containing protein that is ubiquitously expressed and may function as a tumor suppressor. CCDC6 is an ATM substrate involved in genotoxic stress response and maintaining genome stability. It negatively regulates PPP4C enzymatic activity as part of the response to DNA damage. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the RET proto-oncogene is the cause of thyroid papillary carcinoma. In immunohistochemistry of normal tissue, CCDC6 has cytoplasmic positivity in most tissues, with strongest expression in fallopian tubes.

References: PLoS One. 2012; 7(5): e36177, PMID: 22655027; The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804, Targe: Human CCDC6, Synonym: CCDC6 | D10S170 | H4 | Protein H4 | TPC | TST1 | PTC, Hos: Rabbit, Clonalit: Polyclonal, Conjugation: Unconjugated, Purificatio: Immunoaffinity purified, Modification: Unmodified, Immunoge: LP-11151, synthetic peptide, Application: IHC - Paraffin (5 µg/ml), Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more: None, Presentatio: PBS, 0.1% Sodium Azide, Storag: Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About CCDC: Uniprot: Q16204 NCBI: NM_005436 NP_005427.2

Cat: RW-52-65266-70